- Adam Hamilton (1880–1952) New Zealand politician
- Adam Hamilton (musician) American guitarist
- Al Hamilton (born 1946) Canadian ice hockey player
- Alexa Hamilton, American actress
- Alfred Douglas-Hamilton, 13th Duke of Hamilton (1862–1940) Scottish nobleman and sailor.
- Alfred Starr Hamilton (1914–2005) American poet
- Alice Hamilton (1869–1970) American medical researcher
- Allen Hamilton (1798–1864) a founding father of Fort Wayne, Indiana
- Alvin Hamilton (1912–2004) Canadian politician
- Amanda Hamilton Scottish nutritionist and television presenter
- Angus Douglas-Hamilton, 15th Duke of Hamilton (1938–2010), Scottish nobleman
- Angus Falconer Douglas-Hamilton (1863–1915) Scottish recipient of the Victoria Cross
- Anne Hamilton, 3rd Duchess of Hamilton (1631–1716) Scottish noblewoman
- Antoine Hamilton (1646–1720) French classical author
- Antony Hamilton (1952–1995) Australian actor
- Arthur Hamilton, songwriter, author of Cry Me a River
- Arthur Hamilton, Lord Hamilton (born 1942) Scottish judge
- Ashley Hamilton (born 1974) American actor
- Barbara Hamilton (1926–1996), a Canadian actor
- Barbara Hamilton, a Manitoba judge
- Ben Hamilton (born 1977) American football player
- Bernie Hamilton (born 1928) American actor
- Bethany Hamilton (born 1990), American surfer
- Betty Hamilton (1904–1994) British Trotskyist
- Björn Hamilton (born 1945) Swedish politician
- Blayney Hamilton (1872–1946) Irish cricketer
- Brutus Hamilton (1900–1970) American athlete
- Bryan Hamilton (born 1946) Northern Irish football player
- Carrie Hamilton (1963–2002) American actress
- Chico Hamilton (born 1921) jazz band leader
- Christine Hamilton (born 1949) English television personality, wife of former MP Neil Hamilton
- Chuck Hamilton (born 1939) Canadian ice hockey player
- Cicely Hamilton (1872–1952) English actress and writer
- Claire Hamilton voice actress
- Clark Hamilton American politician
- Clayton Hamilton (born 1881), American dramatic critic
- Clive Hamilton Director of The Australia Institute
- Constance Hamilton (1862–1945) Canadian politician
- Cornelius S. Hamilton (1821–1867) U.S. politician
- Cosmo Hamilton (1870–1942) English playwright and novelist
- Craig Hamilton (born 1979) Scottish rugby union player
- Curtis Hamilton (born 1985) American football player
- Cyril Hamilton (1909–1941) English cricketer
- Dana Hamilton (born 1950) American hammered dulcimer player
- Darryl Hamilton (born 1964) Baseball player
- Dean Hamilton (born 1961) Canadian actor and director
- Derrick Hamilton (born 1981 ) American football player
- Derrick Hamilton (basketball) (born 1966) American basketball player
- Des Hamilton (born 1976) English footballer
- Diane Hamilton (born 1925) American heiress and founder of Tradition Records
- Diana Hamilton British writer of romance novels
- Don Hamilton (1887–1959) American football player
- Donald Hamilton (1916–2006) U.S. writer
- Doreen Hamilton (born 1951) Canadian politician
- Doug Hamilton (soccer) (1963–2006) president and general manager of the Los Angeles Galaxy soccer team
- Douglas Hamilton, 8th Duke of Hamilton (1756–1799) Scottish peer
- Douglas Douglas-Hamilton, 14th Duke of Hamilton (1903–1973) Scottish nobleman and pioneering aviator
- Eamon Hamilton, musician, frontman of Brakes
- Earl Hamilton (1891–1968) American baseball player
- Earl J. Hamilton (1899–1989) American historian
- Edith Hamilton (1867–1963) writer on mythology
- Edmond Hamilton, a sci-fi writer
- Emily Hamilton British Actress
- Emma, Lady Hamilton (1761–1815) lady friend of Lord Nelson
- Eric Hamilton (born 1953), American football coach
- Erin Hamilton (born 1968) American singer
- Lord Ernest Hamilton (1858–1939) British politician
- Eugene Hamilton (1910–2005) American obstetrician, writer, and medical researcher
- Eugene Lee-Hamilton (1845–1907) English poet
- Fabian Hamilton (born 1955) British politician
- Filippa Palmstierna Hamilton (born 1985) Swedish-French fashion model
- Finley Hamilton (1886–1940) American politician
- Francis Buchanan-Hamilton (1762–1829) Scottish physician
- Franklin Elmer Ellsworth Hamilton (1866–1918) American Bishop of the Methodist Episcopal Church
- Fred C. Hamilton, Canadian politician
- Frederic C. Hamilton American oilman and philanthropist
- Gary Hamilton (born 1980) Northern Irish footballer
- Gay Hamilton (born 1943) Scottish actress
- Gene Hamilton mountain bike racer
- Geoff Hamilton (1936–1996) British gardener and broadcaster
- Gerald Hamilton (c. 1888–1970) British writer
- Gilbert Van Tassel Hamilton (1877–1943) American physician and writer
- Gustav Hamilton (late 1650s - 1691), known as the governor of Enniskillen in Northern Ireland
- Guy Hamilton, English film director
- Hans Hamilton (c. 1758–1822) Anglo-Irish politician
- Hans Hamilton, 4th Baron HolmPatrick (born 1955) British politician
- Harley Hamilton (conductor) (1861 – 1933) American conductor, composer and violinist
- Harold P. Hamilton (1924–2003) American college president and state government official
- Harry Hamilton (born 1962) American football player.
- Henrietta Hamilton (1780–1857) wife of Sir Charles Hamilton, and painter
- Homer Hamilton (1913–1997) Canadian politician
- Hubert Hamilton (1861–1914) British General
- Hugo Hamilton (born 1953) Irish writer
- Ion Hamilton, 1st Baron HolmPatrick (1839–1898) Anglo-Irish politician
- Jackie Hamilton (1937–2003) British comedian
- Jackie Hamilton (ice hockey) (born 1925) Canadian ice hockey player
- Jan Hamilton (born 1964) first officer in the British Army to complete gender re-assignment from male to female
- Jane Hamilton (born 1957) American novelist
- Jane Eaton Hamilton (born 1954) Canadian short story writer, poet and photographer
- Janet Hamilton (1795–1873) Scottish poet
- Jo Hamilton (1827–1904) California Attorney General
- Jo Hamilton British musician
- Jon Hamilton American radio science correspondent
- Joel Hamilton, American producer/engineer/musician
- José Ignacio García Hamilton (born 1943) Argentine writer
- Josh Hamilton (actor) (born 1969)
- Josh Hamilton (born 1981), American baseball player
- Julian Hamilton (born 1976) Australian musician
- Justin Hamilton (born 1982) American football player
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- Kathleen Hamilton, Duchess of Abercorn (1905–1990) Mistress of the Robes to Queen Elizabeth II
- Kevan Hamilton (born 1934) Australian rules footballer
- Keith Hamilton (born 1971) American football player
- Kenneth Hamilton Scottish pianist
- Kimberly Hamilton (born 1977) American television soap opera writer
- Kipp Hamilton (1935–1981) American actress
- Kyle Hamilton (rower) (born 1978)
- Laird Hamilton (born 1964) American big-wave surfer
- Lance Hamilton (born 1973) New Zealand cricketer
- Larry Hamilton (1931–1996) American professional wrestler
- Laurell K. Hamilton, a writer (horror, sci-fi, fantasy)
- Laurentine Hamilton (1826–1882) American Presbyterian, the Unitarian minister
- Lee Hamilton (sports) talk show host
- Lee H. Hamilton (born 1931) US politician
- Leonard Hamilton (born 1948) American basketball coach
- Lewis Hamilton (born 1985), British Formula One driver
- Lewis Hamilton (footballer) (born 1984) English footballer
- Lillias Hamilton (1858–1925) English woman doctor and author
- Linda Hamilton, actress
- Lisa Gay Hamilton, actress
- Lloyd Hamilton (1891–1935 ) silent film star
- Lois Hamilton (1943–1999) model, author, actress, artist and aviatrix
- Lowry Hamilton (1869–1936) Irish cricketer
- Lucy Hamilton (also known as China Burg) member of the No Wave band Mars
- Lyn Hamilton Canadian author of archaeological mystery novels
- Lynell Hamilton (born 1985) American football player
- Lynn Hamilton (born 1930) African-American actress
- Lynne Hamilton British singer and Evangelist minister
- Mahlon Hamilton (1880–1960) American actor
- Marci Hamilton American scholar in constitutional law
- Marcus Hamilton (American football) (born 1984)
- Margaret Hamilton (1902–1985) actress best known for The Wizard of Oz
- Marguerite Hamilton (died 1998) American author
- Marvin Hamilton (born 1988) English footballer
- Mary Hamilton (bigamist)
- Mary Hamilton and "Miss Mary" Case
- Mary Agnes Hamilton (1882–1966) British politician
- Mary Victoria Hamilton (1850–1922) aristocrat
- Masha Hamilton author and journalist
- Maximilian Reichsgraf von Hamilton (1714-1776) prince bishop of Olmütz
- Max Hamilton (1912–1988) medical statistician
- Melinda Page Hamilton American actress
- Michelle Hamilton (born 1948) Playmate
- Milo Hamilton (born 1927) Baseball announcer
- Milton H. Hamilton, Jr (born 1932) former majority leader in the Tennessee State Senate
- Morgan C. Hamilton (1809–1893) American politician
- Murray Hamilton (1923–1986) American actor
- Natasha Hamilton (born 1982) English singer and member of Atomic Kitten
- Nick Hamilton (born 1959) professional wrestling referee
- Nigel Hamilton (civil servant) Northern Ireland civil servant
- Nigel Hamilton (author) Biographer of Field Marshal Bernard Montgomery
- Norman R. Hamilton (1877–1964) US politician
- Page Hamilton (born 1960) guitarist, singer and record producer
- Paris Hamilton (born 1981) American football player
- Patricia Hamilton (born 1938) Canadian actress
- Paul Hamilton (1762–1816) United States Secretary of the Navy
- Paula Hamilton, supermodel, best known for 80s VW TV ad "Changes"
- Pep Hamilton American football coach
- Phillip Hamilton (born 1961) writer
- Pierpont M. Hamilton (1898–1982) United States Army Air Forces officer
- R.H. Hamilton first head coach of the Baylor college football program from 1899–1900
- Ralph Hamilton (1921–1993), American professional basketball player
- Ray Hamilton (born 1951) American football player
- Raymond Hamilton (1913–1935) American murderer who was executed
- Raymond Hamilton (soccer) U.S. soccer player
- Reg Hamilton (1914–1991) Canadian ice hockey player
- Reggie Hamilton, American bass guitar player
- Remy Hamilton (born 1974) American football player
- Robin Hamilton American politician
- Roland Hamilton (1886–1953) British politician
- Rollin Hamilton (1898–1951), American animator of, for example, Lady, Play Your Mandolin! and I Haven't Got a Hat
- Roy Hamilton (1929–1969) American singer
- Roy "Royalty" Hamilton (born 1980) African-American songwriter
- Roy Hamilton (basketball) (born 1957) American basketball player
- Russ Hamilton American poker player
- Russ Hamilton (singer) (born 1932) English singer
- Ruth Hamilton (1898–2008) American radio talk show host and politician
- Sarah Hamilton American actress
- Sarah Jane Hamilton (born 1971) pornographic actress
- Schuyler Hamilton, (1822–1903), American soldier
- Sean Hamilton US radio host
- Simon Hamilton Northern Ireland politician
- Suzanna Hamilton (born 1960) English actress
- Suzy Favor-Hamilton (born 1968) American middle distance runner
- Tang Hamilton (born 1978) American National Basketball player
- Todd Hamilton, an American professional golfer
- Trevor Hamilton (born 1982) Northern Irish murderer
- Tyler Hamilton (born 1971) American professional road bicycle racer
- Tyler Hamilton (reporter) (born 1970) Canadian
- Venson Hamilton (born 1977) American-Spanish basketball player
- Victoria Hamilton (born 1971) British actress
- W. D. Hamilton British evolutionary biologist
- W. O. Hamilton American athletics coach
- Walter Kerr Hamilton (1808–1869) Anglican Bishop of Salisbury
- Walter Richard Pollock Hamilton, (1856–1879), Irish recipient of the Victoria Cross
- Wes Hamilton (born 1953) American football player
- Willoughby Hamilton (1864–1943) Irish tennis player
- Zendon Hamilton (born 1975) American basketball player
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